Physician-supervised ketamine treatment at our Tucson locations. When antidepressants fail, there's still hope.

What Is Ketamine Therapy?

Ketamine therapy is a physician-supervised medical treatment using low-dose ketamine infusions to rapidly treat treatment-resistant depression, PTSD, and chronic pain. Unlike traditional antidepressants that take 6-8 weeks, ketamine works within 24-72 hours by resetting neural pathways through NMDA receptor modulation and BDNF production. Treatment involves 6 initial infusions over 2-3 weeks, followed by maintenance sessions every 2-4 weeks.

Success rate: 70-80% even when other treatments have failed
Cost: $450 per session
Time per session: 2-3 hours
Results timeline: 24-72 hours
Available in: Tucson (2 locations), Fountain Hills, Yuma

Book Your Consultation today to get started!

Medical Ketamine Therapy in Tucson: When You've Tried Everything Else

You've seen 5+ doctors. Tried multiple antidepressants. Done years of therapy. Nothing has worked. You don't have to keep suffering.

Medical ketamine therapy is a breakthrough treatment for people with treatment-resistant depression, PTSD, chronic pain syndromes, and suicidal ideation. At our Tucson locations, we combine ketamine with complementary therapies like NAD+ for cellular recovery and CBD for inflammation through our signature Mind Mend protocol.

Ketamine vs Traditional Antidepressants: By The Numbers

How Ketamine Works: The Science Behind Rapid Relief

Traditional antidepressants target serotonin and take weeks to work—if they work at all. Ketamine operates through entirely different mechanisms:

NMDA Receptor Modulation

NMDA (N-Methyl-D-Aspartate) receptors are glutamate receptors in your brain that, when overactive, contribute to depression and chronic pain. Ketamine temporarily blocks these receptors, interrupting negative thought patterns and pain signals within hours—not weeks.

BDNF Production & Neuroplasticity

BDNF (Brain-Derived Neurotrophic Factor) is a protein that helps grow new neural connections. Ketamine causes a surge in BDNF production within hours, literally rewiring your brain to form new, healthier thought patterns. This process, called neuroplasticity, is why ketamine creates lasting changes—not just temporary symptom relief.

Default Mode Network Reset

The default mode network (DMN) is your brain's "autopilot" that controls rumination, self-criticism, and repetitive negative thinking. In depression, the DMN becomes hyperactive and rigid, trapping you in negative thought loops. Ketamine temporarily disrupts this network, allowing your brain to form new, more flexible patterns and perspectives.

Glutamate System Rebalancing

Unlike SSRIs that target serotonin (which only 30-40% of depressed people respond to), ketamine modulates the glutamate system—the brain's primary excitatory neurotransmitter. This addresses a different biological pathway, which is why it works when serotonin-based medications don't.

Not Your Average Ketamine Clinic: Integrated Protocols for Lasting Results

At Rejuvenate, we don't just administer ketamine and send you home. Our Mind Mend protocol combines:

Ketamine Infusions
Rapid neural pathway reset and NMDA receptor modulation

NAD+ Therapy
Cellular regeneration, mitochondrial support, and enhanced mental clarity
Learn more about NAD+ →

CBD Infusions
Anti-inflammatory effects, enhanced neuroplasticity, anxiety reduction
Learn more about medical CBD →

Functional Medicine Support
Root cause analysis, nutritional optimization, hormone balancing through our partner practice

Integration Support
Ongoing guidance between sessions, journal prompts, lifestyle recommendations for lasting transformation

This is why Tucson residents choose Rejuvenate over generic ketamine clinics—we treat the whole person, not just symptoms.

Conditions We Treat with Ketamine in Tucson

Treatment-Resistant Depression

When 2 or more antidepressants have failed. The longer you've struggled, the more important it is to try something fundamentally different—not another SSRI variation.

PTSD & Complex Trauma

Including first responder trauma, military PTSD, childhood trauma, and complex PTSD (C-PTSD). Ketamine helps break the cycle of re-experiencing trauma by disrupting fear-based memory reconsolidation.

Chronic Pain Syndromes

Fibromyalgia, CRPS (Complex Regional Pain Syndrome), neuropathic pain, centralized pain. Ketamine addresses the central sensitization that makes chronic pain resistant to traditional pain management.

Suicidal Ideation

When rapid relief is critical. Multiple studies show ketamine reduces suicidal thoughts within 24 hours—a lifesaving timeline advantage over traditional medications.

If you or someone you love is in immediate danger or thinking about harming themselves, please call or text 988 to reach the Suicide & Crisis Lifeline. You’re not alone, and help is available 24/7.

Bipolar Depression

Carefully monitored protocols that address depressive episodes without triggering mania. Requires thorough psychiatric evaluation.

Severe Anxiety

When traditional anxiolytics aren't enough. Particularly effective for anxiety with strong rumination and panic components.

Not sure if you're a candidate? Book a Free Consultation Today! →

Our Tucson Medical Team

Dr. James Dill, MD - Medical Director

• Board-certified Emergency Medicine physician

• 15+ years treating acute psychiatric crises in the ER

• Specialized training in ketamine protocols for mental health

• Left traditional medicine to provide real healing: "This is why I went into medicine."

Jamie Dill, RN BSN - Clinical Director

• Critical care nursing background with 10+ years experience

• Specialized training in IV therapy and patient comfort

• Expert in managing ketamine infusions and integration support

• "Watching patients finally feel better never gets old."

What to Expect During Your Ketamine Treatment in Tucson

Step 1: Before Your Infusion

$25 Comprehensive Consultation with Dr. Dill

• Complete medical and psychiatric history review

• Current medication review and interaction screening

• Personalized protocol design based on your specific condition

• All questions answered before you commit

• Consultation fee applied to first treatment cost

Pre-Treatment Preparation (48 Hours Before)

• Detailed preparation guide sent via email

• Dietary recommendations (light meal, avoid alcohol)

• What to bring (comfortable clothes, music preferences)

• Transportation arrangements (you'll need a driver)

Step 2: During Your 2-3 Hour Infusion

Arrival & Setup (15-20 minutes)

• Vital sign baseline (blood pressure, heart rate, oxygen)

• IV line placement by experienced nursing staff

• Comfortable private treatment room setup

• Optional eye mask and noise-canceling headphones

Infusion Period (45-60 minutes)

• Carefully titrated dosing for your comfort

• Continuous monitoring by medical team

• Most patients experience mild dissociation (feeling "floaty" or dreamlike)

• This dissociative experience is part of the therapeutic process

• You remain conscious and safe throughout

Recovery Period (60-90 minutes)

• Gradual return to baseline

• Vital sign monitoring until stable

• Light refreshments available

• Integration recommendations and journal prompts

• Clearance from medical team before departure

Option to Combine Therapies

• Add NAD+ for enhanced cellular recovery (+$200-400)

• Add CBD for anti-inflammatory benefits (+$100-200)

• Learn about Mind Mend protocol →

Step 3: After Your Infusion

Immediate (Same Day)

• You'll need a driver (effects wear off within 2 hours but we require transportation)

• Most patients feel relaxed and contemplative

• Rest recommended for remainder of day

48-Hour Follow-Up Call

• Check-in from our clinical team

• Side effect assessment

• Integration support and journaling guidance

• Questions answered

Ongoing Protocol

• Initial series: 6 infusions over 2-3 weeks (Monday-Wednesday-Friday typical schedule)

• Maintenance: Every 2-4 weeks as needed based on your response

• Some patients need monthly maintenance, others quarterly

• Personalized to your biology and response

Ketamine Therapy Pricing - Tucson Locations

We believe in complete pricing transparency to help you make informed decisions:

Payment Options

✓ Payment Plans - Through CareCredit (0% financing available)
✓ HSA/FSA - Fully eligible for health savings accounts
✓ Superbills - Provided for potential out-of-network insurance reimbursement
✓ Insurance - While most plans don't cover ketamine infusions yet, some patients receive partial reimbursement

Cost Comparison Reality Check:

• 6-session ketamine series: $2,400

• vs. 2 years of ineffective antidepressants: $2,000+ (plus side effects, lost time)

• vs. Weekly therapy for 6 months: $5,200-10,400

• vs. Lost productivity from depression: Incalculable

Schedule your free consultation to discuss your specific situation →

Our Tucson Ketamine Therapy Locations

Rejuvenate at Selah Salon

621 North 6th Avenue
Tucson, AZ 85705
(520) 276-5777

Location Benefits:

• Central Tucson near University of Arizona

• Private treatment rooms with spa-like atmosphere

• Easy access from I-10 and downtown

• Free parking available

Hours: Monday - Friday: 9am - 6pm
Saturday: By appointment
Sunday: Closed

Book Consultation at Selah → | View location details →

Rejuvenate at Calm Clinic

4578 N 1st Ave # 100
Tucson, AZ 85705
(520) 241-4996

Location Benefits:

• Specialized mental health focus

• Dedicated space for longer integration sessions

• Quiet, therapeutic environment

Hours: [Add hours]

Book Consultation at Calm Clinic → | View location details →

View all Arizona locations →

Frequently Asked Questions About Ketamine Therapy in Tucson

How quickly will I feel results from ketamine therapy?

Most patients experience improvement within 24-72 hours after their first infusion. About 70% of Tucson patients report significant relief after 2-3 sessions, even when other treatments have failed for years. Some patients notice changes during the infusion itself—a sudden lifting of the "heaviness" or a new perspective on their situation.

Is ketamine therapy safe?

When administered by experienced medical professionals like our ER physician Dr. Dill, ketamine therapy is very safe. We use sub-anesthetic doses (much lower than surgical doses) and continuously monitor vital signs throughout treatment at our Tucson medical facilities. Ketamine has been used safely in medicine for over 50 years—it's even on the WHO's list of essential medicines.

How many ketamine treatments will I need?

Most patients start with a series of 6 infusions over 2-3 weeks at either our Selah or Calm Clinic location in Tucson, then transition to maintenance treatments every 2-4 weeks as needed. Your protocol is personalized based on your response. Some patients maintain remission with monthly "booster" infusions, others need them more or less frequently.

What's the difference between Rejuvenate and other Tucson ketamine clinics?

Rejuvenate offers physician-supervised, integrated protocols combining ketamine with complementary therapies like NAD+ and CBD. We're not just a "ketamine clinic"—we're a comprehensive medical practice focused on lasting transformation, not quick fixes. Our emergency medicine physician brings critical care expertise to monitoring and safety, and our integration support helps make changes last beyond the infusion room.

Can I drive after ketamine treatment?

No, you'll need a driver for all ketamine appointments at our Tucson locations. The dissociative effects wear off within 2 hours, but we require transportation for safety. Plan to have someone pick you up or use a rideshare service.

Do you offer ketamine therapy at all your Arizona locations?

Yes, ketamine therapy is available at both Tucson locations (Selah Salon and Calm Clinic) and via mobile concierge service in Fountain Hills. For Yuma, please contact us to discuss current availability and scheduling.

How much does ketamine therapy cost in Tucson?

Single infusions start at $450, with 6-session packages at $2,400 (saving you $300). Our $25 consultation (applied to treatment) includes full cost breakdown and payment options discussion tailored to your situation. We accept HSA/FSA, offer CareCredit financing, and provide superbills for insurance.

Will insurance cover my ketamine therapy?

Most insurance plans don't cover ketamine infusions for mental health yet. However, we accept HSA/FSA funds, offer payment plans through CareCredit (including 0% interest options), and provide superbills for potential out-of-network reimbursement. Our consultation includes insurance navigation support. Some patients receive partial reimbursement—we'll help you understand your specific situation.

What does the dissociative experience feel like?

Most patients describe feeling "floaty," detached from their body, or like they're in a dreamlike state. Some experience visual changes (colors seem brighter, patterns) or time passing differently. The experience is generally pleasant and many patients find it insightful or even spiritual. You remain conscious and safe throughout, and the effects fade within 30-60 minutes after the infusion ends.

Can I combine ketamine with my current antidepressants?

In most cases, yes. Ketamine works through different mechanisms than SSRIs, SNRIs, or other antidepressants, so they can typically be combined safely. Dr. Dill will review all your current medications during the consultation to check for any interactions. Some patients eventually taper off other medications after successful ketamine treatment, but this is always done gradually and under medical supervision.

What if ketamine doesn't work for me?

About 20-30% of patients don't respond adequately to ketamine alone. In these cases, we explore: (1) adjusting the protocol (different dosing, adding NAD+ or CBD), (2) addressing underlying factors (hormones, inflammation, sleep), (3) alternative treatments through our functional medicine partnerships. Our goal is finding what works for YOU, not just offering a single protocol.

Is ketamine addictive?

When used at therapeutic doses under medical supervision, ketamine is not addictive. The doses we use (0.5-0.8 mg/kg) are much lower than recreational doses, and the supervised clinical setting prevents abuse potential. However, people with current substance abuse issues are not good candidates for ketamine therapy. We screen thoroughly during the consultation.

How is this different from Spravato (esketamine)?

Spravato is a nasal spray version of esketamine (the S-isomer of ketamine) that's FDA-approved for treatment-resistant depression. It requires in-office monitoring and has more insurance restrictions. IV ketamine (what we provide) uses racemic ketamine (both R and S isomers), is typically more effective, allows for more precise dosing, and provides a fuller therapeutic experience. Spravato costs $600-900 per session through insurance; our ketamine is often more affordable and flexible.

Ready to Finally Feel Like Yourself Again?

You've tried everything. The medications that didn't work or had unbearable side effects. The therapy that helped a little but not enough. Multiple providers— Nothing has worked.

You don't have to keep suffering.

Our integrated ketamine therapy has helped hundreds of Tucson residents reclaim their lives when nothing else worked. Many of our patients are healthcare professionals, Mayo Clinic refugees, and people who've exhausted every traditional option.

If you're still reading this, you're ready for something different.

What Happens Next:

1. Schedule your $25 consultation (applied to treatment)

2. Meet with Dr. Dill to discuss your history and create your protocol

3. Start treatment typically within 1-2 weeks

4. Experience relief within 24-72 hours for most patients

Choose Your Location:

📍 Selah Salon (Central Tucson)
Book Consultation at Selah →

📍 Calm Clinic (West Tucson)
Book Consultation at Calm →

Email: info@rejuvenate-az.com
Phone/Text: (520) 276-5777

Physician-supervised ketamine therapy in Tucson, Arizona. Board-certified emergency medicine physician. Serving patients across Southern Arizona including Oro Valley, Marana, Green Valley, Vail, and surrounding communities.