10.28.2025

5 mins

Why Your Labs Are Normal But You Still Feel Terrible: The Hidden Truth About Standard Blood Tests

a close up of a section of a human's stomach

Dr. James Dill, MD

Co-Founder, Rejuvenate

You’ve been to multiple doctors. You’ve had countless blood tests. Every time, you hear the same frustrating message: “Your labs look normal.”

Yet you wake up exhausted. Your body aches. Your brain feels foggy. You know something isn’t right, but the medical system keeps telling you there’s nothing wrong.

If this sounds familiar, you’re not alone. Many patients experience real, life-altering symptoms despite being told their lab results are fine. The truth is, your labs might be “normal”—but that doesn’t mean they’re optimal.

The Fundamental Problem with “Normal” Lab Ranges

Standard laboratory reference ranges are determined by testing large populations and defining “normal” as the middle 95% of results. This means:

  • 5% of healthy people automatically fall outside the range

  • Many people with early dysfunction still fall within it

  • You’re being compared to a statistical average—not a picture of optimal health

These ranges were built to detect disease, not evaluate well-being.

The Population Problem

Most patients never hear how reference ranges are actually created:

  • They include sick individuals (undiagnosed conditions influence the “normal” range)

  • They vary from lab to lab

  • They don’t reflect optimal physiology, only thresholds for diagnosing disease

What Standard Blood Work Misses

Functional and integrative medicine practitioners often look at deeper patterns that standard panels weren’t designed to detect. These insights are part of the broader functional medicine conversation, even if they aren’t routinely part of conventional testing.

1. Early-Stage Inflammation

Routine blood work may overlook:

  • subtle inflammatory patterns

  • neutrophil-to-lymphocyte ratio

  • red cell distribution width

  • ferritin in clinical context

These often shift years before traditional inflammatory markers become abnormal.

2. Cellular Energy Dysfunction

Mitochondrial stress or early oxidative damage rarely shows up in standard panels, even though these issues commonly affect fatigue, brain fog, and mood.

3. Subclinical Hormonal Imbalances

For example, traditional TSH ranges (0.5–5.0) are broad. Many functional practitioners use narrower “optimal” windows to catch early thyroid dysfunction.

The Functional Medicine Difference: Optimal vs. Normal

Functional medicine, as a field, tends to use narrower, wellness-oriented ranges to better understand what’s happening before symptoms become disease.

This perspective looks at patterns, not isolated numbers.

Real Examples of “Normal” But Not Optimal

Vitamin D

Standard: 20–80 ng/mL

Optimal: 40–60 ng/mL

Ferritin

Standard: 12–300 ng/mL

Optimal: 50–150 ng/mL

Fasting Glucose

Standard: 65–99 mg/dL

Optimal: 70–85 mg/dL

Why Symptoms Appear Before Disease

Your body often sends warning signs long before disease is detectable:

  1. Cellular dysfunction begins

  2. Subclinical changes appear

  3. Labs drift toward the edges of “normal”

  4. Symptoms intensify

  5. Labs finally become abnormal

Traditional medicine typically intervenes at step 5. Functional medicine perspectives focus earlier—on steps 2–3.

The Hidden Patterns in “Normal” Labs

These are examples of patterns functional medicine practitioners look for when interpreting labs through a wellness-first lens:

The Inflammation Pattern

  • High-normal ferritin

  • Slightly elevated platelets

  • RDW above 13%

  • WBC at upper normal

The Energy Depletion Pattern

  • Low-normal B12

  • Ferritin under 50

  • Suboptimal vitamin D

  • Low-normal morning cortisol

The Metabolic Dysfunction Pattern

  • Glucose 90–99 mg/dL

  • Triglyceride-to-HDL ratio above 2

  • High-normal liver enzymes

  • Low-normal sex hormones

These patterns don’t diagnose disease—they help explain symptoms traditional labs often miss.

What Actually Helps: A More Complete Lens

At Rejuvenate, our clinical lens emphasizes:

  • Your symptoms

  • Your history

  • Your physiology

  • How your lab patterns fit into the bigger picture

While we may incorporate expanded testing when clinically appropriate, our approach is grounded in treating the whole person—not just chasing abnormal numbers.

This perspective allows us to explore:

  • possible inflammatory contributors

  • nutrient status

  • cellular energy factors

  • hormonal balance

  • stress physiology

always in partnership with you and your goals.

Your Next Steps: Beyond “Normal”

If you feel unwell despite “normal” labs, here’s what you can do next:

1. Request Expanded Testing

Ask your provider about:

  • Vitamin D deficiency

  • Vitamin b12 deficiency

  • comprehensive nutrient levels

  • fasting insulin

2. Get Your Results Interpreted Through a Broader Lens

Different frameworks—like functional medicine’s focus on patterns and optimal ranges—can help explain why symptoms persist despite normal numbers.

3. Address Root Causes, Not Just Symptoms

Rather than masking symptoms, seek clinicians who are committed to understanding why your body is struggling.

The Bottom Line: You’re Not Crazy

Your symptoms are real. Your experience is real. And you deserve more than being told “everything is normal.”

Rejuvenate is committed to a patient-centered approach that goes beyond surface-level lab interpretation and looks at your health from multiple angles to help uncover what’s holding you back.

If you’re ready to dig deeper into your symptoms and explore options that align with your goals, we’re here to support you.

Ready for a different kind of conversation about your health?

Schedule a consultation to take the next step.

Discover how Rejuvenate can transform your health and well-being.

Discover how Rejuvenate can transform your health and well-being.

Discover how Rejuvenate can transform your health and well-being.

10.28.2025

5 mins

Why Your Labs Are Normal But You Still Feel Terrible: The Hidden Truth About Standard Blood Tests

a close up of a section of a human's stomach

Dr. James Dill, MD

Co-Founder, Rejuvenate

You’ve been to multiple doctors. You’ve had countless blood tests. Every time, you hear the same frustrating message: “Your labs look normal.”

Yet you wake up exhausted. Your body aches. Your brain feels foggy. You know something isn’t right, but the medical system keeps telling you there’s nothing wrong.

If this sounds familiar, you’re not alone. Many patients experience real, life-altering symptoms despite being told their lab results are fine. The truth is, your labs might be “normal”—but that doesn’t mean they’re optimal.

The Fundamental Problem with “Normal” Lab Ranges

Standard laboratory reference ranges are determined by testing large populations and defining “normal” as the middle 95% of results. This means:

  • 5% of healthy people automatically fall outside the range

  • Many people with early dysfunction still fall within it

  • You’re being compared to a statistical average—not a picture of optimal health

These ranges were built to detect disease, not evaluate well-being.

The Population Problem

Most patients never hear how reference ranges are actually created:

  • They include sick individuals (undiagnosed conditions influence the “normal” range)

  • They vary from lab to lab

  • They don’t reflect optimal physiology, only thresholds for diagnosing disease

What Standard Blood Work Misses

Functional and integrative medicine practitioners often look at deeper patterns that standard panels weren’t designed to detect. These insights are part of the broader functional medicine conversation, even if they aren’t routinely part of conventional testing.

1. Early-Stage Inflammation

Routine blood work may overlook:

  • subtle inflammatory patterns

  • neutrophil-to-lymphocyte ratio

  • red cell distribution width

  • ferritin in clinical context

These often shift years before traditional inflammatory markers become abnormal.

2. Cellular Energy Dysfunction

Mitochondrial stress or early oxidative damage rarely shows up in standard panels, even though these issues commonly affect fatigue, brain fog, and mood.

3. Subclinical Hormonal Imbalances

For example, traditional TSH ranges (0.5–5.0) are broad. Many functional practitioners use narrower “optimal” windows to catch early thyroid dysfunction.

The Functional Medicine Difference: Optimal vs. Normal

Functional medicine, as a field, tends to use narrower, wellness-oriented ranges to better understand what’s happening before symptoms become disease.

This perspective looks at patterns, not isolated numbers.

Real Examples of “Normal” But Not Optimal

Vitamin D

Standard: 20–80 ng/mL

Optimal: 40–60 ng/mL

Ferritin

Standard: 12–300 ng/mL

Optimal: 50–150 ng/mL

Fasting Glucose

Standard: 65–99 mg/dL

Optimal: 70–85 mg/dL

Why Symptoms Appear Before Disease

Your body often sends warning signs long before disease is detectable:

  1. Cellular dysfunction begins

  2. Subclinical changes appear

  3. Labs drift toward the edges of “normal”

  4. Symptoms intensify

  5. Labs finally become abnormal

Traditional medicine typically intervenes at step 5. Functional medicine perspectives focus earlier—on steps 2–3.

The Hidden Patterns in “Normal” Labs

These are examples of patterns functional medicine practitioners look for when interpreting labs through a wellness-first lens:

The Inflammation Pattern

  • High-normal ferritin

  • Slightly elevated platelets

  • RDW above 13%

  • WBC at upper normal

The Energy Depletion Pattern

  • Low-normal B12

  • Ferritin under 50

  • Suboptimal vitamin D

  • Low-normal morning cortisol

The Metabolic Dysfunction Pattern

  • Glucose 90–99 mg/dL

  • Triglyceride-to-HDL ratio above 2

  • High-normal liver enzymes

  • Low-normal sex hormones

These patterns don’t diagnose disease—they help explain symptoms traditional labs often miss.

What Actually Helps: A More Complete Lens

At Rejuvenate, our clinical lens emphasizes:

  • Your symptoms

  • Your history

  • Your physiology

  • How your lab patterns fit into the bigger picture

While we may incorporate expanded testing when clinically appropriate, our approach is grounded in treating the whole person—not just chasing abnormal numbers.

This perspective allows us to explore:

  • possible inflammatory contributors

  • nutrient status

  • cellular energy factors

  • hormonal balance

  • stress physiology

always in partnership with you and your goals.

Your Next Steps: Beyond “Normal”

If you feel unwell despite “normal” labs, here’s what you can do next:

1. Request Expanded Testing

Ask your provider about:

  • Vitamin D deficiency

  • Vitamin b12 deficiency

  • comprehensive nutrient levels

  • fasting insulin

2. Get Your Results Interpreted Through a Broader Lens

Different frameworks—like functional medicine’s focus on patterns and optimal ranges—can help explain why symptoms persist despite normal numbers.

3. Address Root Causes, Not Just Symptoms

Rather than masking symptoms, seek clinicians who are committed to understanding why your body is struggling.

The Bottom Line: You’re Not Crazy

Your symptoms are real. Your experience is real. And you deserve more than being told “everything is normal.”

Rejuvenate is committed to a patient-centered approach that goes beyond surface-level lab interpretation and looks at your health from multiple angles to help uncover what’s holding you back.

If you’re ready to dig deeper into your symptoms and explore options that align with your goals, we’re here to support you.

Ready for a different kind of conversation about your health?

Schedule a consultation to take the next step.

Discover how Rejuvenate can transform your health and well-being.

Discover how Rejuvenate can transform your health and well-being.

Discover how Rejuvenate can transform your health and well-being.