10.28.2025
5 mins
Why Your Labs Are Normal But You Still Feel Terrible: The Hidden Truth About Standard Blood Tests


Dr. James Dill, MD
Co-Founder, Rejuvenate
You’ve been to multiple doctors. You’ve had countless blood tests. Every time, you hear the same frustrating message: “Your labs look normal.”
Yet you wake up exhausted. Your body aches. Your brain feels foggy. You know something isn’t right, but the medical system keeps telling you there’s nothing wrong.
If this sounds familiar, you’re not alone. Many patients experience real, life-altering symptoms despite being told their lab results are fine. The truth is, your labs might be “normal”—but that doesn’t mean they’re optimal.
The Fundamental Problem with “Normal” Lab Ranges
Standard laboratory reference ranges are determined by testing large populations and defining “normal” as the middle 95% of results. This means:
5% of healthy people automatically fall outside the range
Many people with early dysfunction still fall within it
You’re being compared to a statistical average—not a picture of optimal health
These ranges were built to detect disease, not evaluate well-being.
The Population Problem
Most patients never hear how reference ranges are actually created:
They include sick individuals (undiagnosed conditions influence the “normal” range)
They vary from lab to lab
They don’t reflect optimal physiology, only thresholds for diagnosing disease
What Standard Blood Work Misses
Functional and integrative medicine practitioners often look at deeper patterns that standard panels weren’t designed to detect. These insights are part of the broader functional medicine conversation, even if they aren’t routinely part of conventional testing.
1. Early-Stage Inflammation
Routine blood work may overlook:
subtle inflammatory patterns
neutrophil-to-lymphocyte ratio
red cell distribution width
ferritin in clinical context
These often shift years before traditional inflammatory markers become abnormal.
2. Cellular Energy Dysfunction
Mitochondrial stress or early oxidative damage rarely shows up in standard panels, even though these issues commonly affect fatigue, brain fog, and mood.
3. Subclinical Hormonal Imbalances
For example, traditional TSH ranges (0.5–5.0) are broad. Many functional practitioners use narrower “optimal” windows to catch early thyroid dysfunction.
The Functional Medicine Difference: Optimal vs. Normal
Functional medicine, as a field, tends to use narrower, wellness-oriented ranges to better understand what’s happening before symptoms become disease.
This perspective looks at patterns, not isolated numbers.
Real Examples of “Normal” But Not Optimal
Vitamin D
Standard: 20–80 ng/mL
Optimal: 40–60 ng/mL
Ferritin
Standard: 12–300 ng/mL
Optimal: 50–150 ng/mL
Fasting Glucose
Standard: 65–99 mg/dL
Optimal: 70–85 mg/dL
Why Symptoms Appear Before Disease
Your body often sends warning signs long before disease is detectable:
Cellular dysfunction begins
Subclinical changes appear
Labs drift toward the edges of “normal”
Symptoms intensify
Labs finally become abnormal
Traditional medicine typically intervenes at step 5. Functional medicine perspectives focus earlier—on steps 2–3.
The Hidden Patterns in “Normal” Labs
These are examples of patterns functional medicine practitioners look for when interpreting labs through a wellness-first lens:
The Inflammation Pattern
High-normal ferritin
Slightly elevated platelets
RDW above 13%
WBC at upper normal
The Energy Depletion Pattern
Low-normal B12
Ferritin under 50
Suboptimal vitamin D
Low-normal morning cortisol
The Metabolic Dysfunction Pattern
Glucose 90–99 mg/dL
Triglyceride-to-HDL ratio above 2
High-normal liver enzymes
Low-normal sex hormones
These patterns don’t diagnose disease—they help explain symptoms traditional labs often miss.
What Actually Helps: A More Complete Lens
At Rejuvenate, our clinical lens emphasizes:
Your symptoms
Your history
Your physiology
How your lab patterns fit into the bigger picture
While we may incorporate expanded testing when clinically appropriate, our approach is grounded in treating the whole person—not just chasing abnormal numbers.
This perspective allows us to explore:
possible inflammatory contributors
nutrient status
cellular energy factors
hormonal balance
stress physiology
always in partnership with you and your goals.
Your Next Steps: Beyond “Normal”
If you feel unwell despite “normal” labs, here’s what you can do next:
1. Request Expanded Testing
Ask your provider about:
Vitamin D deficiency
Vitamin b12 deficiency
comprehensive nutrient levels
fasting insulin
2. Get Your Results Interpreted Through a Broader Lens
Different frameworks—like functional medicine’s focus on patterns and optimal ranges—can help explain why symptoms persist despite normal numbers.
3. Address Root Causes, Not Just Symptoms
Rather than masking symptoms, seek clinicians who are committed to understanding why your body is struggling.
The Bottom Line: You’re Not Crazy
Your symptoms are real. Your experience is real. And you deserve more than being told “everything is normal.”
Rejuvenate is committed to a patient-centered approach that goes beyond surface-level lab interpretation and looks at your health from multiple angles to help uncover what’s holding you back.
If you’re ready to dig deeper into your symptoms and explore options that align with your goals, we’re here to support you.
Ready for a different kind of conversation about your health?
Schedule a consultation to take the next step.

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Discover how Rejuvenate can transform your health and well-being.

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10.28.2025
5 mins
Why Your Labs Are Normal But You Still Feel Terrible: The Hidden Truth About Standard Blood Tests


Dr. James Dill, MD
Co-Founder, Rejuvenate
You’ve been to multiple doctors. You’ve had countless blood tests. Every time, you hear the same frustrating message: “Your labs look normal.”
Yet you wake up exhausted. Your body aches. Your brain feels foggy. You know something isn’t right, but the medical system keeps telling you there’s nothing wrong.
If this sounds familiar, you’re not alone. Many patients experience real, life-altering symptoms despite being told their lab results are fine. The truth is, your labs might be “normal”—but that doesn’t mean they’re optimal.
The Fundamental Problem with “Normal” Lab Ranges
Standard laboratory reference ranges are determined by testing large populations and defining “normal” as the middle 95% of results. This means:
5% of healthy people automatically fall outside the range
Many people with early dysfunction still fall within it
You’re being compared to a statistical average—not a picture of optimal health
These ranges were built to detect disease, not evaluate well-being.
The Population Problem
Most patients never hear how reference ranges are actually created:
They include sick individuals (undiagnosed conditions influence the “normal” range)
They vary from lab to lab
They don’t reflect optimal physiology, only thresholds for diagnosing disease
What Standard Blood Work Misses
Functional and integrative medicine practitioners often look at deeper patterns that standard panels weren’t designed to detect. These insights are part of the broader functional medicine conversation, even if they aren’t routinely part of conventional testing.
1. Early-Stage Inflammation
Routine blood work may overlook:
subtle inflammatory patterns
neutrophil-to-lymphocyte ratio
red cell distribution width
ferritin in clinical context
These often shift years before traditional inflammatory markers become abnormal.
2. Cellular Energy Dysfunction
Mitochondrial stress or early oxidative damage rarely shows up in standard panels, even though these issues commonly affect fatigue, brain fog, and mood.
3. Subclinical Hormonal Imbalances
For example, traditional TSH ranges (0.5–5.0) are broad. Many functional practitioners use narrower “optimal” windows to catch early thyroid dysfunction.
The Functional Medicine Difference: Optimal vs. Normal
Functional medicine, as a field, tends to use narrower, wellness-oriented ranges to better understand what’s happening before symptoms become disease.
This perspective looks at patterns, not isolated numbers.
Real Examples of “Normal” But Not Optimal
Vitamin D
Standard: 20–80 ng/mL
Optimal: 40–60 ng/mL
Ferritin
Standard: 12–300 ng/mL
Optimal: 50–150 ng/mL
Fasting Glucose
Standard: 65–99 mg/dL
Optimal: 70–85 mg/dL
Why Symptoms Appear Before Disease
Your body often sends warning signs long before disease is detectable:
Cellular dysfunction begins
Subclinical changes appear
Labs drift toward the edges of “normal”
Symptoms intensify
Labs finally become abnormal
Traditional medicine typically intervenes at step 5. Functional medicine perspectives focus earlier—on steps 2–3.
The Hidden Patterns in “Normal” Labs
These are examples of patterns functional medicine practitioners look for when interpreting labs through a wellness-first lens:
The Inflammation Pattern
High-normal ferritin
Slightly elevated platelets
RDW above 13%
WBC at upper normal
The Energy Depletion Pattern
Low-normal B12
Ferritin under 50
Suboptimal vitamin D
Low-normal morning cortisol
The Metabolic Dysfunction Pattern
Glucose 90–99 mg/dL
Triglyceride-to-HDL ratio above 2
High-normal liver enzymes
Low-normal sex hormones
These patterns don’t diagnose disease—they help explain symptoms traditional labs often miss.
What Actually Helps: A More Complete Lens
At Rejuvenate, our clinical lens emphasizes:
Your symptoms
Your history
Your physiology
How your lab patterns fit into the bigger picture
While we may incorporate expanded testing when clinically appropriate, our approach is grounded in treating the whole person—not just chasing abnormal numbers.
This perspective allows us to explore:
possible inflammatory contributors
nutrient status
cellular energy factors
hormonal balance
stress physiology
always in partnership with you and your goals.
Your Next Steps: Beyond “Normal”
If you feel unwell despite “normal” labs, here’s what you can do next:
1. Request Expanded Testing
Ask your provider about:
Vitamin D deficiency
Vitamin b12 deficiency
comprehensive nutrient levels
fasting insulin
2. Get Your Results Interpreted Through a Broader Lens
Different frameworks—like functional medicine’s focus on patterns and optimal ranges—can help explain why symptoms persist despite normal numbers.
3. Address Root Causes, Not Just Symptoms
Rather than masking symptoms, seek clinicians who are committed to understanding why your body is struggling.
The Bottom Line: You’re Not Crazy
Your symptoms are real. Your experience is real. And you deserve more than being told “everything is normal.”
Rejuvenate is committed to a patient-centered approach that goes beyond surface-level lab interpretation and looks at your health from multiple angles to help uncover what’s holding you back.
If you’re ready to dig deeper into your symptoms and explore options that align with your goals, we’re here to support you.
Ready for a different kind of conversation about your health?
Schedule a consultation to take the next step.

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Discover how Rejuvenate can transform your health and well-being.

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Discover how Rejuvenate can transform your health and well-being.
